Just trying out Firefox 3 Beta 4 and I'm impressed. The first most obvious difference I noticed is the speed of GMail. It's lightning fast. The over look 'n' feel of this beta is very nice and is a big improvement over Firefox 2.*. The memory usage is also a lot less than Firefox 2, so far anyway, though running it with a new/clean profile always helps.
I have it installed along side Firefox 2 but so far I think I'll stick with using this Beta version as I've had no problems so far. Looking forward to the final release.